Try the following steps:

• Disable/Enable loot filter by:
  • Press or Hold X
  • Press or Hold Z
• Disable/Enable Ground Tooltips
  • Press Alt + X
  • Press Alt + Z
    • If you use Nvidia GeForce Experience, this is bound to Alt + Z by default and is a good idea to rebind this or rebind the Ground Tooltips option in game.

If you have followed all the steps above and are still unable to pick up loot, please submit an In Game Bug Reports with your player data and a screenshot of the loot attached as this information is incredibly helpful to the team.

If you need help submitting a bug report, please follow this link.

Right-click keybinding not working

This is a known issue. If you're unable to pick up items using the right-click keybinding, try one of these workarounds:

• Use left-click to pick up items instead.
• Switch to "Alternative" interaction mode in Gameplay Options.